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Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats

Overview of attention for article published in American Journal of Physiology: Heart & Circulatory Physiology, December 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 2,607)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
15 news outlets
blogs
2 blogs
twitter
25 tweeters
facebook
2 Facebook pages
reddit
1 Redditor

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
6 Mendeley
Title
Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats
Published in
American Journal of Physiology: Heart & Circulatory Physiology, December 2018
DOI 10.1152/ajpheart.00536.2018
Pubmed ID
Authors

Tomasz Huc, Adrian Drapala, Marta Gawrys, Marek Konop, Klaudia Bielinska, Ewelina Zaorska, Emilia Samborowska, Aleksandra Wyczalkowska-Tomasik, Leszek Pączek, Michal Dadlez, Marcin Ufnal

Abstract

Several studies suggest negative effects of trimethylamine oxide (TMAO) on the circulatory system. However, a number of studies showed protective functions of TMAO, a piezolyte and osmolyte, in animals exposed to high hydrostatic and/or osmotic stress. We evaluated the effects of TMAO treatment on the development of hypertension and its complications in male, Spontaneously Hypertensive Rats maintained on water (SHR-WATER) and SHR drinking TMAO water solution from weaning (SHR-TMAO). Wistar-Kyoto rats (WKY) were used as normotensive controls to discriminate between age-dependent and hypertension-dependent changes. Telemetry measurements of blood pressure (BP) were performed in rats between 7th and 16th week of life. Anaesthetized rats underwent echocardiographic, electrocardiographic and direct left ventricular end-diastolic pressure (LVEDP) measurements. HE and van Gieson staining for histopathological evaluation were performed. Plasma TMAO measured by chromatography coupled with mass spectrometry was significantly higher in SHR-WATER than in WKY (≈20%). TMAO treatment increased plasma TMAO by 4-5-fold, and did not affect the development of hypertension in SHR. 16-week-old SHR-WATER and SHR-TMAO (12-week-TMAO-treatment) showed similar BP, angiopathy and cardiac hypertrophy. However, SHR-TMAO had lower plasma NT-proBNP, LVEDP, and cardiac fibrosis. In contrast to age-matched WKY, 60-week-old SHR showed hypertensive angiopathy and heart failure with preserved ejection fraction. In comparison to SHR-WATER, SHR-TMAO (56-week-TMAO-treatment) showed significantly lower plasma NT-proBNP and vasopressin, significantly lower LVEDP and cardiac fibrosis. In conclusion, 4-5-fold increase in plasma TMAO does not exert negative effects on the circulatory system. In contrast, increased dietary TMAO seems to reduce diastolic dysfunction in pressure-overloaded heart in rats.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 50%
Student > Master 2 33%
Student > Doctoral Student 2 33%
Student > Ph. D. Student 2 33%
Student > Postgraduate 1 17%
Other 1 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 50%
Medicine and Dentistry 3 50%
Biochemistry, Genetics and Molecular Biology 2 33%
Nursing and Health Professions 2 33%
Materials Science 1 17%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 146. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2019.
All research outputs
#92,152
of 12,953,360 outputs
Outputs from American Journal of Physiology: Heart & Circulatory Physiology
#6
of 2,607 outputs
Outputs of similar age
#3,971
of 263,706 outputs
Outputs of similar age from American Journal of Physiology: Heart & Circulatory Physiology
#2
of 98 outputs
Altmetric has tracked 12,953,360 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,607 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,706 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.